Mathematical modelling predicts synergistic anti-tumor effects of combining a macrophage-based, hypoxia-targeted, gene therapy with chemotherapy
نویسندگان
چکیده
Disclosure of Potential Conflicts of Interest: J Dobson is a consultant to and shareholder in nanoTherics Limited, which is commercialising magnetic nanoparticle-based gene transfection technology. J Dobson, CE Lewis and HM Byrne are co-inventors of a relevant patent applied for by Keele University: Targeted Therapy. Patent Pending (Application Nos. 60/789,185; P112277GB; WO2007113572 – Filed: 2006).
منابع مشابه
Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy.
Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery, limiting the efficacy of many conventional therapies such as chemotherapy. Because many macrophages accumulate in hypoxic regions of tumors, one way to target tumor cells in these regions could be to use genetically engineered macrophages that express therapeutic genes when exposed to hypoxia. Systemic deli...
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تاریخ انتشار 2011